The northern border is the Danube River, with Romania on the other bank. The territory of the district covers part of the Danube plain and parts of Stara Planina. The Ogosta, Scat and Iskar rivers pass through the region. The international highway from Central Europe-Craiova-Vidin-Sofia-Kulata-Thessaloniki passes through Vratsa District. The Iskar Gorge connects the area with the settlements located to the south of the Balkan Mountains. The first nuclear power plant on the Balkans was built on the bank of the Danube River near Kozloduy.

With its diverse, unique and beautiful scenery, Vratsa District offers excellent opportunities for tourism - ecological, rural, hunting and cultural. Among the protected areas in the region are Vrachanski Balkan Nature Park, Ledenika Cave, Skoklya Falls, Vratsa Gorge, God's Bridge (rock formations near the village of Lilyache, the Ritlite Rocks around Lyutibrod, 15-century-old oaks near Byala Slatina, the Vola area, where the poet and revolutionist Hristo Botev was killed, etc.